Reproducible particle size and shape image analysis

Shading Corrector

Our software's unique shading correction feature ensures even illumination for all your images captured using the system’s camera.

1. Before shading correction
2. After shading correction

Calibration Settings

Calibrate your system manually or automatically. Associate different calibration settings for each objective lens or camera. Store an unlimited number of settings to be used later at the touch of a button.

Auto Exposure

Once you have set the initial target intensity, you can duplicate lighting conditions any time with a simple click of the Auto Exposure button.

Adjusting camera shutter speed manually is not necessary.

Extended Depth of Field

The Multi-Layer Grab feature allows you to work on a sharp composite image of an uneven surface, made up of several image slices captured at various depths. This function can adapt to either manual or motorized focus systems.

USB II Camera

High frame rates and excellent image resolution.

These cameras are easy to install with a single wire connection.

Volume Measurements

Clemex PSA features excellent resolution and detection of micronized particles as small as 0.5 microns. 

Particle volume determination is based on absolute 2D measurements and thus not limited to spheroids.

Relative Gray Threshold

The system automatically adjusts threshold when background varies from field to field so that your objects are always perfectly detected.

Object Tracking

Primarily a built-in spreadsheet, the Clemex PSA's Data Browser also remembers the positions of all analyzed objects, even in multiple-field environments. This allows you to validate detected objects, delete artifacts, and sort the final results.

Contrast Threshold

Transparency, low contrast and more or less perceptible outlines make some objects hard to distinguish.

Contrast Thresholding is ideal for faint objects on a filter, thin-walled cells and variable thickness crystals.

Isolate Populations

Clemex software offers you the possibility to isolate objects and measure them separately.

The transfer can be based on morphology, color or size. Some common parameters include sphericity, aspect ratio, roughness, length, area and hue.

Color Detection

Sometimes your images may need the extra flexibility of a Color Threshold to distinguish phases or objects with a particular hue.

The pink phase in the particles on the left can only be detected using Color Threshold.

Characterize Objects

After detecting the objects of interest in your image you can use any number of custom or standard measurements to further classify objects.

Produce and export raw and statistical data for each category of particles, fibers, spheres or irregular objects.

Crossed Fibers Algorithm

A unique algorithm to improve accuracy when defining the length and shape of fibers.
 

This is the first image analysis system capable of proper characterization of fibers or elongated crystals, a very important control issue in the pharmaceutical industry.

True Particle Shape

Characterize particle shape in addition to particle size, to gain a better understanding of how shape can effect the various properties of a product.

Clemex PSA provides true particle shape information which is not determined by “correction factors” but which is rather based on exactly what is seen in the microscope.

Percentiles for Particle Size

These statistics are compiled automatically and are available for all object measures.

Particulartly useful when measuring the size and shape of particles – be it length, sphericity, aspect ratio, roundness, roughness, spherical volume or compactness.

High Throughput

Data collection is achieved through multiple field analysis using a Clemex 4-slide sample holder and motorized stage. Our robotic image analysis system will allow the user to measure large number of slides simultaneously without any operator intervention.

Separate Adjacent Objects

Particles that touch each other can be easily separated with a variety of automated tools. The end result being that each object is counted separately, yielding more precise results.

Statistically Significant Results

Clemex PSA automatically calculates various measurements simultaneously on thousands of individual particles. It is capable of generating statistically significant results in an amazingly short time. The powerful report generator allows speedy data processing and flexible reporting capabilities.

Reproducibility and Traceability

In conjunction with an automated workstation, an image analysis routine can be executed multiple times with no deviation from the initial results. This guarantees reproducibility and traceability of analysis, ensuring accurate results and conforming to 21 CFR Part 11 requirements.

Camera and Microscope

Cameras and automated microscopes can be controlled directly within an imaging script. Automating this step means the following can be changed during analysis without any manual adjustments:

1. calibration / intensity
2. magnification
3. illumination / contrast

Auto Calibration

Using our NIST traceable micrometer, Clemex software automatically calibrates each lens, eliminating operator subjectivity.

The system returns accurate, reproducible and traceable results.

Hot or Cold Stage

The Clemex Vision PE software works in conjunction with hot and cold stage software, accumulating data as the temperature rises and falls and producing results once the analysis is over.